Antisense down-regulation of thymidylate synthase to suppress growth and enhance cytotoxicity of 5-FUdR, 5-FU and Tomudex in HeLa cells

1. Thymidylate synthase (TS), the key enzyme in de novo synthesis of thymidine, is an important target for antitumour chemotherapy. It was hypothesized that antisense oligonucleotide down-regulation of TS mRNA would decrease TS levels and enhance the cytotoxicity of inhibitors of TS, including the p...

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Main Authors: Ferguson, Peter J, Collins, Olga, Dean, Nicholas M, DeMoor, Janice, Sha-Li, Chen, Vincent, Mark D, Koropatnick, James
Formato: Artigo
Idioma:Inglês
Publicado: 1999
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Papers
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1566173/
https://ncbi.nlm.nih.gov/pubmed/10482907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702728
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