Despite substantial degradation, 2-arachidonoylglycerol is a potent full efficacy agonist mediating CB(1) receptor-dependent G-protein activation in rat cerebellar membranes

1. Two endocannabinoids, arachidonoyl ethanolamide (AEA) and 2-arachidonoylglycerol (2-AG) bind and activate G-protein-coupled cannabinoid receptors, but limited data exist on their relative ability to activate G-proteins. 2. Here we assess agonist potency and efficacy of various cannabinoids, inclu...

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Autores principales: Savinainen, Juha R, Järvinen, Tomi, Laine, Krista, Laitinen, Jarmo T
Formato: Artigo
Lenguaje:Inglês
Publicado: 2001
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Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572991/
https://ncbi.nlm.nih.gov/pubmed/11588122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704297
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