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Identification of WIN55212-3 as a competitive neutral antagonist of the human cannabinoid CB(2) receptor
1. Several G protein-coupled receptors (GPCRs), including cannabinoid CB(1) and CB(2) receptors, show constitutive activity under heterologous expression. Such a tonic response is generated in the absence of an activating ligand, and can be inhibited by inverse agonists. Neutral antagonists, however...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1576178/ https://ncbi.nlm.nih.gov/pubmed/15852035 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706230 |
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