Identification of WIN55212-3 as a competitive neutral antagonist of the human cannabinoid CB(2) receptor

1. Several G protein-coupled receptors (GPCRs), including cannabinoid CB(1) and CB(2) receptors, show constitutive activity under heterologous expression. Such a tonic response is generated in the absence of an activating ligand, and can be inhibited by inverse agonists. Neutral antagonists, however...

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Hlavní autoři: Savinainen, Juha R, Kokkola, Tarja, Salo, Outi M H, Poso, Antti, Järvinen, Tomi, Laitinen, Jarmo T
Médium: Artigo
Jazyk:Inglês
Vydáno: 2005
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Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1576178/
https://ncbi.nlm.nih.gov/pubmed/15852035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706230
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