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An optimized approach to study endocannabinoid signaling: evidence against constitutive activity of rat brain adenosine A(1) and cannabinoid CB(1) receptors
1. At nanomolar concentrations, SR141716 and AM251 act as specific and selective antagonists of the cannabinoid CB(1) receptor. In the micromolar range, these compounds were shown to inhibit basal G-protein activity, and this is often interpreted to implicate constitutive activity of the CB(1) recep...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1574161/ https://ncbi.nlm.nih.gov/pubmed/14623770 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705577 |
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