An optimized approach to study endocannabinoid signaling: evidence against constitutive activity of rat brain adenosine A(1) and cannabinoid CB(1) receptors

1. At nanomolar concentrations, SR141716 and AM251 act as specific and selective antagonists of the cannabinoid CB(1) receptor. In the micromolar range, these compounds were shown to inhibit basal G-protein activity, and this is often interpreted to implicate constitutive activity of the CB(1) recep...

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Hlavní autoři: Savinainen, Juha R, Saario, Susanna M, Niemi, Riku, Järvinen, Tomi, Laitinen, Jarmo T
Médium: Artigo
Jazyk:Inglês
Vydáno: 2003
Témata:
Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1574161/
https://ncbi.nlm.nih.gov/pubmed/14623770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705577
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