Assessment of agonism at G-protein coupled receptors by phosphatidic acid and lysophosphatidic acid in human embryonic kidney 293 cells

Several different molecular species of phosphatidic acid (PA) bind to a G-protein coupled receptor (GPCR) to induce activation of the p42/p44 mitogen-activated protein kinase (p42/p44 MAPK) pathway in HEK 293 cells. PA is active at low nanomolar concentrations and the response is sensitive to pertus...

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Bibliografske podrobnosti
Main Authors: Alderton, Forbes, Sambi, Balwinder, Tate, Rothwelle, Pyne, Nigel J, Pyne, Susan
Format: Artigo
Jezik:Inglês
Izdano: 2001
Teme:
Special Reports
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572939/
https://ncbi.nlm.nih.gov/pubmed/11522591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704278
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