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Role of Phosphatidic Acid in the Coupling of the ERK Cascade
The production of phosphatidic acid plays a crucial role in the activation of the ERK cascade. This role was linked to the binding of phosphatidate to a specific polybasic site within the kinase domain of Raf-1. Here we show that phosphatidate promotes ERK phosphorylation in intact cells but does no...
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Main Authors: | , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
American Society for Biochemistry and Molecular Biology
2008
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2606017/ https://ncbi.nlm.nih.gov/pubmed/18952605 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804633200 |
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