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Role of Phosphatidic Acid in the Coupling of the ERK Cascade

The production of phosphatidic acid plays a crucial role in the activation of the ERK cascade. This role was linked to the binding of phosphatidate to a specific polybasic site within the kinase domain of Raf-1. Here we show that phosphatidate promotes ERK phosphorylation in intact cells but does no...

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Detalhes bibliográficos
Main Authors: Kraft, Catherine A., Garrido, José Luis, Fluharty, Eric, Leiva-Vega, Luis, Romero, Guillermo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2606017/
https://ncbi.nlm.nih.gov/pubmed/18952605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804633200
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