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Real-time analysis of dopamine: antagonist interactions at recombinant human D(2long) receptor upon modulation of its activation state

1. Antipsychotic drugs may mediate their therapeutic effects not only by preventing the binding of dopamine but also by decreasing the propensity of the dopamine receptor to assume an active R* state. Ligand-mediated activation and blockade of the recombinant human D(2long) receptor was investigated...

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Detalhes bibliográficos
Main Authors: Pauwels, Petrus J, Tardif, Stéphanie, Wurch, Thierry, Colpaert, Francis C
Formato: Artigo
Idioma:Inglês
Publicado em: 2001
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572932/
https://ncbi.nlm.nih.gov/pubmed/11522600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704243
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