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Inhibition of poly (ADP-ribose) synthetase by gene disruption or inhibition with 5-iodo-6-amino-1,2-benzopyrone protects mice from multiple-low-dose-streptozotocin-induced diabetes
1. Activation of poly(ADP-ribose) synthetase (PARS, also termed polyADP-ribose polymerase or PARP) has been proposed as a major mechanism contributing to β-cell destruction in type I diabetes. In the present study, we have investigated the role of PARS in mediating the induction of diabetes and β-ce...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2001
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1572858/ https://ncbi.nlm.nih.gov/pubmed/11454665 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704156 |
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