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Nociceptin inhibits cough in the guinea-pig by activation of ORL(1) receptors
We studied the central and peripheral antitussive effect of ORL(1) receptor activation with nociceptin/orphanin FQ in conscious guinea-pigs. In guinea-pig cough studies, nociceptin/orphanin FQ (10, 30, and 90 μg) given directly into the CNS by an intracerebroventricular (i.c.v.) route inhibited coug...
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Autori principali: | , , , , , , , , , , |
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Natura: | Artigo |
Lingua: | Inglês |
Pubblicazione: |
2001
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Soggetti: | |
Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1572678/ https://ncbi.nlm.nih.gov/pubmed/11250866 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703954 |
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