Nociceptin inhibits cough in the guinea-pig by activation of ORL(1) receptors

We studied the central and peripheral antitussive effect of ORL(1) receptor activation with nociceptin/orphanin FQ in conscious guinea-pigs. In guinea-pig cough studies, nociceptin/orphanin FQ (10, 30, and 90 μg) given directly into the CNS by an intracerebroventricular (i.c.v.) route inhibited coug...

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Detalhes bibliográficos
Main Authors: McLeod, Robbie L, Parra, Leonard E, Mutter, Jennifer C, Erickson, Christine H, Carey, Galen J, Tulshian, Deen B, Fawzi, Ahmad B, Smith-Torhan, April, Egan, Robert W, Cuss, Francis M, Hey, John A
Formato: Artigo
Idioma:Inglês
Publicado em: 2001
Assuntos:
Special Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572678/
https://ncbi.nlm.nih.gov/pubmed/11250866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703954
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