A synthetic agonist at the orphanin FQ/nociceptin receptor ORL1: Anxiolytic profile in the rat

The biochemical and behavioral effects of a nonpeptidic, selective, and brain-penetrant agonist at the ORL1 receptor are reported herein. This low molecular weight compound {(1S,3aS)-8- (2,3,3a,4,5,6-hexahydro-1H-phenalen-1-yl)-1-phenyl-1,3,8-triaza- spiro[4.5]decan-4-one} has high affinity for reco...

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Dettagli Bibliografici
Autori principali: Jenck, François, Wichmann, Juergen, Dautzenberg, Frank M., Moreau, Jean-Luc, Ouagazzal, Abdel M., Martin, James R., Lundstrom, Kenneth, Cesura, Andrea M., Poli, Sonia M., Roever, Stephan, Kolczewski, Sabine, Adam, Geo, Kilpatrick, Gavin
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences 2000
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC18336/
https://ncbi.nlm.nih.gov/pubmed/10758169
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