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A synthetic agonist at the orphanin FQ/nociceptin receptor ORL1: Anxiolytic profile in the rat

The biochemical and behavioral effects of a nonpeptidic, selective, and brain-penetrant agonist at the ORL1 receptor are reported herein. This low molecular weight compound {(1S,3aS)-8- (2,3,3a,4,5,6-hexahydro-1H-phenalen-1-yl)-1-phenyl-1,3,8-triaza- spiro[4.5]decan-4-one} has high affinity for reco...

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Jenck, François, Wichmann, Juergen, Dautzenberg, Frank M., Moreau, Jean-Luc, Ouagazzal, Abdel M., Martin, James R., Lundstrom, Kenneth, Cesura, Andrea M., Poli, Sonia M., Roever, Stephan, Kolczewski, Sabine, Adam, Geo, Kilpatrick, Gavin
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2000
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18336/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10758169/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.090514397
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