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Targeted disruption of the orphanin FQ/nociceptin gene increases stress susceptibility and impairs stress adaptation in mice

The neuropeptide orphanin FQ (also known as nociceptin; OFQ/N) has been implicated in modulating stress-related behavior. OFQ/N was demonstrated to reverse stress-induced analgesia and possess anxiolytic-like activity after central administration. To further study physiological functions of OFQ/N, w...

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Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Köster, Anja, Montkowski, Alexandra, Schulz, Stefan, Stübe, Eva-Maria, Knaudt, Kristina, Jenck, Francois, Moreau, Jean-Luc, Nothacker, Hans-Peter, Civelli, Olivier, Reinscheid, Rainer K.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 1999
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC17908/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10468628/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.18.10444
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