Targeted disruption of the orphanin FQ/nociceptin gene increases stress susceptibility and impairs stress adaptation in mice

The neuropeptide orphanin FQ (also known as nociceptin; OFQ/N) has been implicated in modulating stress-related behavior. OFQ/N was demonstrated to reverse stress-induced analgesia and possess anxiolytic-like activity after central administration. To further study physiological functions of OFQ/N, w...

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Bibliographic Details
Main Authors: Köster, Anja, Montkowski, Alexandra, Schulz, Stefan, Stübe, Eva-Maria, Knaudt, Kristina, Jenck, Francois, Moreau, Jean-Luc, Nothacker, Hans-Peter, Civelli, Olivier, Reinscheid, Rainer K.
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 1999
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC17908/
https://ncbi.nlm.nih.gov/pubmed/10468628
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