Selective mGluR5 antagonists MPEP and SIB-1893 decrease NMDA or glutamate-mediated neuronal toxicity through actions that reflect NMDA receptor antagonism

1. The metabotropic glutamate receptors (mGluRs) are a family of G-protein linked receptors that can be divided into three groups (group I, II and III). A number of studies have implicated group I mGluR activation in acute neuronal injury, but until recently it was not possible to pharmacologically...

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Hlavní autoři: O'Leary, Deirdre M, Movsesyan, Vilen, Vicini, Stefano, Faden, Alan I
Médium: Artigo
Jazyk:Inglês
Vydáno: 2000
Témata:
Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572472/
https://ncbi.nlm.nih.gov/pubmed/11090117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703715
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