Effects of sodium on agonist efficacy for G-protein activation in μ-opioid receptor-transfected CHO cells and rat thalamus

1. Sodium ions inhibit spontaneous G(i)/G(o)-coupled receptor activity and promote agonist-induced responses in vitro. The effects of sodium on the relative efficacy of opioid agonists for G-protein activation was measured by guanosine-5′-O-(γ-(35)S)-triphosphate ([(35)S]-GTPγS) binding in membranes...

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Bibliographic Details
Main Authors: Selley, Dana E, Cao, Cheng-Chun, Liu, Qixu, Childers, Steven R
Format: Artigo
Language:Inglês
Published: 2000
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Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572152/
https://ncbi.nlm.nih.gov/pubmed/10882382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703382
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