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Effects of sodium on agonist efficacy for G-protein activation in μ-opioid receptor-transfected CHO cells and rat thalamus
1. Sodium ions inhibit spontaneous G(i)/G(o)-coupled receptor activity and promote agonist-induced responses in vitro. The effects of sodium on the relative efficacy of opioid agonists for G-protein activation was measured by guanosine-5′-O-(γ-(35)S)-triphosphate ([(35)S]-GTPγS) binding in membranes...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2000
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1572152/ https://ncbi.nlm.nih.gov/pubmed/10882382 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703382 |
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