Structural determinants of the partial agonist-inverse agonist properties of 6′-azidohex-2′-yne-Δ(8)-tetrahydrocannabinol at cannabinoid receptors

1. We have extended previous investigations of four analogues of Δ(8)-tetrahydrocannabinol (Δ(8)-THC): 6′-azidohex-2′-yne-Δ(8)-THC (O-1184), 6′-azidohex-cis-2′-ene-Δ(8)-THC (O-1238) and octyl-2′-yne-Δ(8)-THC (O-584) and its 1-deoxy-analogue (O-1315). 2. O-1184, O-1238 and O-584 displaced [(3)H]-CP55...

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Autors principals: Ross, Ruth A, Gibson, T Michael, Stevenson, Lesley A, Saha, Bijali, Crocker, Peter, Razdan, Raj K, Pertwee, Roger G
Format: Artigo
Idioma:Inglês
Publicat: 1999
Matèries:
Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1571677/
https://ncbi.nlm.nih.gov/pubmed/10516656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702836
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