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Comparison of novel cannabinoid partial agonists and SR141716A in the guinea-pig small intestine

1. The controversial nature of the CB(1) receptor antagonist, SR141716A, in the guinea-pig small intestine was investigated by comparing it with four analogues of Δ(8)-tetrahydrocannabinol (Δ(8)-THC): O-1184, O-1238, O-584 and O-1315. 2. These compounds (10–1000 nM) inhibited the electrically-evoked...

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Detalhes bibliográficos
Main Authors: Coutts, Angela A, Brewster, Nicola, Ingram, Tracey, Razdan, Raj K, Pertwee, Roger G
Formato: Artigo
Idioma:Inglês
Publicado em: 2000
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1571886/
https://ncbi.nlm.nih.gov/pubmed/10683188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703094
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