Myc is a Notch1 transcriptional target and a requisite for Notch1-induced mammary tumorigenesis in mice

To explore the potential involvement of aberrant Notch1 signaling in breast cancer pathogenesis, we have used a transgenic mouse model. In these animals, mouse mammary tumor virus LTR-driven expression of the constitutively active intracellular domain of the Notch1 receptor (N1(IC)) causes developme...

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Bibliografiska uppgifter
Huvudupphovsmän: Klinakis, Apostolos, Szabolcs, Matthias, Politi, Katerina, Kiaris, Hippokratis, Artavanis-Tsakonas, Spyros, Efstratiadis, Argiris
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2006
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1570422/
https://ncbi.nlm.nih.gov/pubmed/16751266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0603371103
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