Modulation of Notch Signaling Elicits Signature Tumors and Inhibits Hras1-Induced Oncogenesis in the Mouse Mammary Epithelium

Deregulation of Notch signaling, which normally affects a broad spectrum of cell fates, has been implicated in various neoplastic conditions. Here we describe a transgenic mouse model, which demonstrates that expression of a constitutively active form of the Notch1 receptor in the mammary epithelium...

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Bibliografiska uppgifter
Huvudupphovsmän: Kiaris, Hippokratis, Politi, Katerina, Grimm, Lisa M., Szabolcs, Matthias, Fisher, Peter, Efstratiadis, Argiris, Artavanis-Tsakonas, Spyros
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Investigative Pathology 2004
Ämnen:
Animal Models
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1618582/
https://ncbi.nlm.nih.gov/pubmed/15277242
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