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Myc is a Notch1 transcriptional target and a requisite for Notch1-induced mammary tumorigenesis in mice
To explore the potential involvement of aberrant Notch1 signaling in breast cancer pathogenesis, we have used a transgenic mouse model. In these animals, mouse mammary tumor virus LTR-driven expression of the constitutively active intracellular domain of the Notch1 receptor (N1(IC)) causes developme...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1570422/ https://ncbi.nlm.nih.gov/pubmed/16751266 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0603371103 |
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