Liver-specific deletion of acetyl-CoA carboxylase 1 reduces hepatic triglyceride accumulation without affecting glucose homeostasis

In animals, liver and white adipose are the main sites for the de novo fatty acid synthesis. Deletion of fatty acid synthase or acetyl-CoA carboxylase (ACC) 1 in mice resulted in embryonic lethality, indicating that the de novo fatty acid synthesis is essential for embryonic development. To understa...

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Bibliographische Detailangaben
Hauptverfasser: Mao, Jianqiang, DeMayo, Francesco J., Li, Huiguang, Abu-Elheiga, Lutfi, Gu, Ziwei, Shaikenov, Tattym E., Kordari, Parichher, Chirala, Subrahmanyam S., Heird, William C., Wakil, Salih J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2006
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1570106/
https://ncbi.nlm.nih.gov/pubmed/16717184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0603115103
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