Accumulation of Recessive Lethal Mutations in Saccharomyces cerevisiae mlh1 Mismatch Repair Mutants Is Not Associated With Gross Chromosomal Rearrangements

We examined mismatch repair (MMR)-defective diploid strains of budding yeast grown for ∼160 generations to determine whether decreases in spore viability due to the uncovering of recessive lethal mutations correlated with an increase in gross chromosomal rearrangements (GCRs). No GCRs were detected...

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Detalhes bibliográficos
Main Authors: Heck, Julie Akiko, Gresham, David, Botstein, David, Alani, Eric
Formato: Artigo
Idioma:Inglês
Publicado em: Copyright © 2006 by the Genetics Society of America 2006
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1569777/
https://ncbi.nlm.nih.gov/pubmed/16816424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.106.059311
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