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A Mutation in the Putative MLH3 Endonuclease Domain Confers a Defect in Both Mismatch Repair and Meiosis in Saccharomyces cerevisiae

Interference-dependent crossing over in yeast and mammalian meioses involves the mismatch repair protein homologs MSH4-MSH5 and MLH1-MLH3. The MLH3 protein contains a highly conserved metal-binding motif DQHA(X)(2)E(X)(4)E that is found in a subset of MLH proteins predicted to have endonuclease acti...

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Библиографические подробности
Главные авторы: Nishant, K. T., Plys, Aaron J., Alani, Eric
Формат: Artigo
Язык:Inglês
Опубликовано: Genetics Society of America 2008
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2429871/
https://ncbi.nlm.nih.gov/pubmed/18505871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.108.086645
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