Multiple Quantitative Trait Loci Modify Cochlear Hair Cell Degeneration in the Beethoven (Tmc1(Bth)) Mouse Model of Progressive Hearing Loss DFNA36

Dominant mutations of transmembrane channel-like gene 1 (TMC1) cause progressive sensorineural hearing loss in humans and Beethoven (Tmc1(Bth/+)) mice. Here we show that Tmc1(Bth/+) mice on a C3HeB/FeJ strain background have selective degeneration of inner hair cells while outer hair cells remain st...

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Detalhes bibliográficos
Main Authors: Noguchi, Yoshihiro, Kurima, Kiyoto, Makishima, Tomoko, de Angelis, Martin Hrabé, Fuchs, Helmut, Frolenkov, Gregory, Kitamura, Ken, Griffith, Andrew J.
Formato: Artigo
Idioma:Inglês
Publicado em: Copyright © 2006 by the Genetics Society of America 2006
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Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1569729/
https://ncbi.nlm.nih.gov/pubmed/16648588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.106.057372
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