Cyclophosphamide enhances glioma virotherapy by inhibiting innate immune responses

Clinical trials are testing oncolytic viruses (OVs) as therapies for cancer. We have shown that animals that have brain tumors and are treated with a herpes simplex virus (HSV)-derived OV live significantly longer when cyclophosphamide (CPA) is preadministered. Here, we explore the mechanisms behind...

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Detalles Bibliográficos
Autores principales: Fulci, Giulia, Breymann, Laura, Gianni, Davide, Kurozomi, Kazuhiko, Rhee, Sarah S., Yu, Jianhua, Kaur, Balveen, Louis, David N., Weissleder, Ralph, Caligiuri, Michael A., Chiocca, E. Antonio
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2006
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1568940/
https://ncbi.nlm.nih.gov/pubmed/16908838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0605496103
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