Polyclonal antibodies to quantitate cis-diamminedichloroplatinum(II)--DNA adducts in cancer patients and animal models.

cis-Diamminedichloroplatinum (II) (cis-DDP), the antitumor drug, is cytotoxic in vitro primarily by binding to DNA and disrupting its normal functions. We have studied cis-DDP modification of DNA in nucleated peripheral blood cells (buffy coat cells) of testicular and ovarian cancer patients receivi...

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Hlavní autoři: Poirier, M C, Reed, E, Zwelling, L A, Ozols, R F, Litterst, C L, Yuspa, S H
Médium: Artigo
Jazyk:Inglês
Vydáno: 1985
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1568668/
https://ncbi.nlm.nih.gov/pubmed/4085451
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