The Wilms tumor gene, Wt1, is required for Sox9 expression and maintenance of tubular architecture in the developing testis

Mutation of the transcription factor and tumor suppressor gene WT1 results in a range of genitourinary anomalies in humans, including 46,XY gonadal dysgenesis, indicating that WT1 plays a critical role in sex determination. However, because knockout of Wt1 in mice results in apoptosis of the genital...

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Autors principals: Gao, Fei, Maiti, Sourindra, Alam, Nargis, Zhang, Zhen, Deng, Jian Min, Behringer, Richard R., Lécureuil, Charlotte, Guillou, Florian, Huff, Vicki
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2006
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1567685/
https://ncbi.nlm.nih.gov/pubmed/16877546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0600994103
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