The Wilms tumor gene, Wt1, is required for Sox9 expression and maintenance of tubular architecture in the developing testis

Mutation of the transcription factor and tumor suppressor gene WT1 results in a range of genitourinary anomalies in humans, including 46,XY gonadal dysgenesis, indicating that WT1 plays a critical role in sex determination. However, because knockout of Wt1 in mice results in apoptosis of the genital...

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Detalhes bibliográficos
Main Authors: Gao, Fei, Maiti, Sourindra, Alam, Nargis, Zhang, Zhen, Deng, Jian Min, Behringer, Richard R., Lécureuil, Charlotte, Guillou, Florian, Huff, Vicki
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1567685/
https://ncbi.nlm.nih.gov/pubmed/16877546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0600994103
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