The Wt1(+/R394W) Mouse Displays Glomerulosclerosis and Early-Onset Renal Failure Characteristic of Human Denys-Drash Syndrome

Renal failure is a frequent and costly complication of many chronic diseases, including diabetes and hypertension. One common feature of renal failure is glomerulosclerosis, the pathobiology of which is unclear. To help elucidate this, we generated a mouse strain carrying the missense mutation Wt1 R...

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Detalhes bibliográficos
Main Authors: Gao, Fei, Maiti, Sourindra, Sun, Guizhi, Ordonez, Nelson G., Udtha, Malini, Deng, Jian Min, Behringer, Richard R., Huff, Vicki
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC525476/
https://ncbi.nlm.nih.gov/pubmed/15509792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.22.9899-9910.2004
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