The Wt1(+/R394W) Mouse Displays Glomerulosclerosis and Early-Onset Renal Failure Characteristic of Human Denys-Drash Syndrome

Renal failure is a frequent and costly complication of many chronic diseases, including diabetes and hypertension. One common feature of renal failure is glomerulosclerosis, the pathobiology of which is unclear. To help elucidate this, we generated a mouse strain carrying the missense mutation Wt1 R...

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Autores principales: Gao, Fei, Maiti, Sourindra, Sun, Guizhi, Ordonez, Nelson G., Udtha, Malini, Deng, Jian Min, Behringer, Richard R., Huff, Vicki
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2004
Materias:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC525476/
https://ncbi.nlm.nih.gov/pubmed/15509792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.22.9899-9910.2004
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