Caenorhabditis elegans ortholog of a diabetes susceptibility locus: oga-1 (O-GlcNAcase) knockout impacts O-GlcNAc cycling, metabolism, and dauer

A dynamic cycle of O-linked N-acetylglucosamine (O-GlcNAc) addition and removal acts on nuclear pore proteins, transcription factors, and kinases to modulate cellular signaling cascades. Two highly conserved enzymes (O-GlcNAc transferase and O-GlcNAcase) catalyze the final steps in this nutrient-dri...

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Autors principals: Forsythe, Michele E., Love, Dona C., Lazarus, Brooke D., Kim, Eun Ju, Prinz, William A., Ashwell, Gilbert, Krause, Michael W., Hanover, John A.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2006
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1567679/
https://ncbi.nlm.nih.gov/pubmed/16882729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0601931103
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