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Nuclear targeting of Akt antagonizes aspects of cardiomyocyte hypertrophy

The serine/threonine kinase Akt regulates cellular survival, proliferation, gene transcription, protein translation, metabolism, and differentiation. Although Akt substrates are found throughout the cell, activated Akt normally accumulates in the nucleus, suggesting that biologically relevant target...

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Bibliografski detalji
Glavni autori: Tsujita, Yasuyuki, Muraski, John, Shiraishi, Isao, Kato, Takahiro, Kajstura, Jan, Anversa, Piero, Sussman, Mark A.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2006
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1567678/
https://ncbi.nlm.nih.gov/pubmed/16882732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0510138103
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