Pim-1 kinase antagonizes aspects of myocardial hypertrophy and compensation to pathological pressure overload

Pim-1 kinase exerts potent cardioprotective effects in the myocardium downstream of AKT, but the participation of Pim-1 in cardiac hypertrophy requires investigation. Cardiac-specific expression of Pim-1 (Pim-WT) or the dominant-negative mutant of Pim-1 (Pim-DN) in transgenic mice together with aden...

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Detalhes bibliográficos
Main Authors: Muraski, John A., Fischer, Kimberlee M., Wu, Weitao, Cottage, Christopher T., Quijada, Pearl, Mason, Matt, Din, Shabana, Gude, Natalie, Alvarez, Roberto, Rota, Marcello, Kajstura, Jan, Wang, Zeping, Schaefer, Erik, Chen, Xiongen, MacDonnel, Scott, Magnuson, Nancy, Houser, Stephen R., Anversa, Piero, Sussman, Mark A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2544549/
https://ncbi.nlm.nih.gov/pubmed/18784362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0709135105
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