Atrial natriuretic peptide promotes cardiomyocyte survival by cGMP-dependent nuclear accumulation of zyxin and Akt

This study delineates a mechanism for antiapoptotic signaling initiated by atrial natriuretic peptide (ANP) stimulation leading to elevation of cGMP levels and subsequent nuclear accumulation of Akt kinase associated with zyxin, a cytoskeletal LIM-domain protein. Nuclear targeting of zyxin induces r...

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Detalhes bibliográficos
Main Authors: Kato, Takahiro, Muraski, John, Chen, Yan, Tsujita, Yasuyuki, Wall, Jason, Glembotski, Christopher C., Schaefer, Erik, Beckerle, Mary, Sussman, Mark A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2005
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1236670/
https://ncbi.nlm.nih.gov/pubmed/16200208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI24280
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