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Genotyping single nucleotide polymorphisms directly from genomic DNA by invasive cleavage reaction on microspheres

Here we report proof-of-principle for a microsphere-based genotyping assay that detects single nucleotide polymorphisms (SNPs) directly from human genomic DNA samples. This assay is based on a structure-specific cleavage reaction that achieves single base discrimination with a 5′-nuclease which reco...

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Udgivet i:Nucleic Acids Res
Principais autores: Rao, Kakuturu V. N., Stevens, Priscilla Wilkins, Hall, Jeff G., Lyamichev, Victor, Neri, Bruce P., Kelso, David M.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2003
Fag:
NAR Methods Online
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC156743/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12771230/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gng066
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