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Structural variations and stabilising modifications of synthetic siRNAs in mammalian cells

Double-stranded short interfering RNAs (siRNA) induce post-transcriptional silencing in a variety of biological systems. In the present study we have investigated the structural requirements of chemically synthesised siRNAs to mediate efficient gene silencing in mammalian cells. In contrast to studi...

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Detalhes bibliográficos
Main Authors: Czauderna, Frank, Fechtner, Melanie, Dames, Sibylle, Aygün, Hüseyin, Klippel, Anke, Pronk, Gijsbertus J., Giese, Klaus, Kaufmann, Jörg
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2003
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC156727/
https://ncbi.nlm.nih.gov/pubmed/12771196
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