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The effect of deep pore mutations on the action of phenylalkylamines on the Kv1.3 potassium channel

1. We investigated the action of the phenylalkylamines verapamil and N-methyl-verapamil on the Kv1.3 potassium channel using the whole-cell configuration of the patch-clamp technique. Our goal was to identify their binding as a prerequisite for using the phenylalkylamines as small, well-defined mole...

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Detalhes bibliográficos
Main Authors: Rauer, Heiko, Grissmer, Stephan
Formato: Artigo
Idioma:Inglês
Publicado em: 1999
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1566106/
https://ncbi.nlm.nih.gov/pubmed/10455250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702599
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