UK-78,282, a novel piperidine compound that potently blocks the Kv1.3 voltage-gated potassium channel and inhibits human T cell activation

1. UK-78,282, a novel piperidine blocker of the T lymphocyte voltage-gated K(+) channel, Kv1.3, was discovered by screening a large compound file using a high-throughput (86)Rb efflux assay. This compound blocks Kv1.3 with a IC(50) of ∼200 nM and 1 : 1 stoichiometry. A closely related compound, CP-1...

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Detalhes bibliográficos
Main Authors: Hanson, Douglas C, Nguyen, Angela, Mather, Robert J, Rauer, Heiko, Koch, Kevin, Burgess, Laurence E, Rizzi, James P, Donovan, Carol B, Bruns, Matthew J, Canniff, Paul C, Cunningham, Ann C, Verdries, Kimberly A, Mena, Edward, Kath, John C, Gutman, George A, Cahalan, Michael D, Grissmer, Stephan, Chandy, K George
Formato: Artigo
Idioma:Inglês
Publicado em: 1999
Assuntos:
Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1565958/
https://ncbi.nlm.nih.gov/pubmed/10372812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702480
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