UK-78,282, a novel piperidine compound that potently blocks the Kv1.3 voltage-gated potassium channel and inhibits human T cell activation

1. UK-78,282, a novel piperidine blocker of the T lymphocyte voltage-gated K(+) channel, Kv1.3, was discovered by screening a large compound file using a high-throughput (86)Rb efflux assay. This compound blocks Kv1.3 with a IC(50) of ∼200 nM and 1 : 1 stoichiometry. A closely related compound, CP-1...

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Bibliografiske detaljer
Main Authors: Hanson, Douglas C, Nguyen, Angela, Mather, Robert J, Rauer, Heiko, Koch, Kevin, Burgess, Laurence E, Rizzi, James P, Donovan, Carol B, Bruns, Matthew J, Canniff, Paul C, Cunningham, Ann C, Verdries, Kimberly A, Mena, Edward, Kath, John C, Gutman, George A, Cahalan, Michael D, Grissmer, Stephan, Chandy, K George
Format: Artigo
Sprog:Inglês
Udgivet: 1999
Fag:
Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1565958/
https://ncbi.nlm.nih.gov/pubmed/10372812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702480
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