A single amino acid confers barbiturate sensitivity upon the GABA ρ(1) receptor

Many structurally diverse general anaesthetics enhance inhibitory neurotransmission in the central nervous system by interacting with the GABA(A) receptor. By contrast, GABA receptors composed of the ρ(1) subunit are anaesthetic-insensitive. Here, we demonstrate that both δ-hexachlorocyclohexane (δ-...

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Bibliographic Details
Main Authors: Belelli, Delia, Pau, Davide, Cabras, Giulia, Peters, John A, Lambert, Jeremy J
Format: Artigo
Language:Inglês
Published: 1999
Subjects:
Special Reports
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1566072/
https://ncbi.nlm.nih.gov/pubmed/10401548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702611
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