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The effect of a transmembrane amino acid on etomidate sensitivity of an invertebrate GABA receptor

1. The γ-aminobutyric acid (GABA)-modulatory and GABA-mimetic actions of etomidate at mammalian GABA(A) receptors are favoured by β(2)- or β(3)- versus β(1)-subunit containing receptors, a selectivity which resides with a single transmembrane amino acid (β(2 N290), β(3 N289), β(1 S290)). Here, we ha...

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Bibliografiske detaljer
Main Authors: McGurk, Karen A, Pistis, Marco, Belelli, Delia, Hope, Anthony G, Lambert, Jeremy J
Format: Artigo
Sprog:Inglês
Udgivet: 1998
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1565349/
https://ncbi.nlm.nih.gov/pubmed/9630337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0701787
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