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Role of blood-brain barrier P-glycoprotein in limiting brain accumulation and sedative side-effects of asimadoline, a peripherally acting analgaesic drug

1. Studies with knockout mice lacking mdr1a P-glycoprotein (P-gp) have previously shown that blood-brain barrier P-gp is important in preventing the accumulation of several drugs in the brain. 2. Asimadoline (EMD 61753) is a peripherally selective κ-opioid receptor agonist which is under development...

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Bibliografski detalji
Glavni autori: Jonker, J W, Wagenaar, E, van Deemter, L, Gottschlich, R, Bender, H M, Dasenbrock, J, Schinkel, A H
Format: Artigo
Jezik:Inglês
Izdano: 1999
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1565984/
https://ncbi.nlm.nih.gov/pubmed/10369454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702497
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