Role of blood-brain barrier P-glycoprotein in limiting brain accumulation and sedative side-effects of asimadoline, a peripherally acting analgaesic drug

Lignende værker

• P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs.
  af: Schinkel, A H, et al.
  Udgivet: (1996)
• Full blockade of intestinal P-glycoprotein and extensive inhibition of blood-brain barrier P-glycoprotein by oral treatment of mice with PSC833.
  af: Mayer, U, et al.
  Udgivet: (1997)
• Substantial excretion of digoxin via the intestinal mucosa and prevention of long-term digoxin accumulation in the brain by the mdr 1a P-glycoprotein.
  af: Mayer, U., et al.
  Udgivet: (1996)
• Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.
  af: Schinkel, A H, et al.
  Udgivet: (1995)
• P-Glycoprotein Limits Oral Availability, Brain Penetration, and Toxicity of an Anionic Drug, the Antibiotic Salinomycin
  af: Lagas, Jurjen S., et al.
  Udgivet: (2008)