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Role of blood-brain barrier P-glycoprotein in limiting brain accumulation and sedative side-effects of asimadoline, a peripherally acting analgaesic drug
1. Studies with knockout mice lacking mdr1a P-glycoprotein (P-gp) have previously shown that blood-brain barrier P-gp is important in preventing the accumulation of several drugs in the brain. 2. Asimadoline (EMD 61753) is a peripherally selective κ-opioid receptor agonist which is under development...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
1999
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1565984/ https://ncbi.nlm.nih.gov/pubmed/10369454 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702497 |
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