JTT-608 restores impaired early insulin secretion in diabetic Goto-Kakizaki rats

1. We investigated the pharmacological effects of a new antidiabetic agent, JTT-608, in comparison with the sulphonylurea tolbutamide, in Goto-Kakizaki (GK) rats, a genetic model of non-obese insulin-dependent diabetes mellitus (NIDDM). 2. In isolated perfused pancreas from GK rats, JTT-608 (200 μM)...

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Main Authors: Ohta, Takeshi, Furukawa, Noboru, Komuro, Goro, Yonemori, Fumihiko, Wakitani, Korekiyo
Formato: Artigo
Idioma:Inglês
Publicado: 1999
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Papers
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1565945/
https://ncbi.nlm.nih.gov/pubmed/10323602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702481
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