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Saxagliptin Restores Vascular Mitochondrial Exercise Response in the Goto-Kakizaki Rat
Cardiovascular disease risk and all-cause mortality are largely predicted by physical fitness. Exercise stimulates vascular mitochondrial biogenesis through endothelial nitric oxide synthase (eNOS), sirtuins, and PPARγ coactivator 1α (PGC-1α), a response absent in diabetes and hypertension. We hypot...
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| Publicado no: | J Cardiovasc Pharmacol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Journal of Cardiovascular Pharmacology
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4320657/ https://ncbi.nlm.nih.gov/pubmed/25264749 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FJC.0000000000000170 |
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