Absence of G-protein activation by μ-opioid receptor agonists in the spinal cord of μ-opioid receptor knockout mice

1. The ability of μ-opioid receptor agonists to activate G-proteins in the spinal cord of μ-opioid receptor knockout mice was examined by monitoring the binding to membranes of the non-hydrolyzable analogue of GTP, guanosine-5′-O-(3-[(35)S]thio)triphosphate ([(35)S]GTPγS). 2. In the receptor binding...

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Bibliographic Details
Main Authors: Narita, Minoru, Mizoguchi, Hirokazu, Narita, Michiko, Sora, Ichiro, Uhl, George R, Tseng, Leon F
Format: Artigo
Language:Inglês
Published: 1999
Subjects:
Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1565830/
https://ncbi.nlm.nih.gov/pubmed/10077238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702330
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