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Inhibition of ornithine decarboxylase potentiates nitric oxide production in LPS-activated J774 cells
1. We have examined whether modulation of the polyamine biosynthetic pathway, through inhibition by α-difluoromethylornithine (DFMO) of the rate limiting enzyme, ornithine decarboxylase (ODC), modulates NO synthesis in J774 macrophages. 2. DFMO potentiated LPS-stimulated nitrite production in both a...
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| Principais autores: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
1998
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1565739/ https://ncbi.nlm.nih.gov/pubmed/9884080 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702231 |
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